Cancer is the leading cause of death in children aged 1 to 14 after accidental injuries. 400,000 children and adolescents develop cancer each year. OHC will focus on paediatric cancers including sarcomas, brain and blood cancers like leukaemias. The new Immunotherapy Centre at University Hospitals in Cleveland will have a strong focus on adolescent cancers. Oxford’s extensive research capabilities in cancer have recently been brought together as Oxford Cancer. 900 researchers are collaborating towards understanding and treating cancer, with particular strengths in early cancer detection and immunotherapies. The NHS commitment to sequencing the DNA of all children with cancer in the UK will make genomics central to designing and testing new targeted therapies.